| Investor | Value | Of portfolio | Shares | Change | Quarter |
|---|---|---|---|---|---|
| Renaissance Technologies | $38.2M | 0.05% | 468.92K | −55% | Q2 2026 |
| Oaktree Capital · Howard Marks | $11.0M | 0.15% | 9.15M | New | Q2 2026 |
From each investor's quarterly 13F filing with the SEC: positions at the quarter's end, reported up to 45 days later. All investors
No member of Congress has disclosed a ARWR trade since 2025.
From House and Senate STOCK Act reports. Members disclose trades, not holdings, as value ranges up to 45 days later, so amounts are estimates and “last move” is a hint at who still holds it, not a position. All recent congress trades
| Date | Insider | Transaction | Shares | Value |
|---|---|---|---|---|
| Aug 17, 2026 | Olukotun Adeoye YDirector | Sale at price 86.96 per share. | 2K | $173.92K |
| Aug 17, 2026 | Perry Michael SDirector | Sale at price 87.30 per share. | 11.6K | $1.01M |
| Jun 14, 2026 | Cohen Matthew GregoryDirector | Stock Award(Grant) at price 0.00 per share. | 11.9K | — |
| May 11, 2026 | Lu Hongbo BDirector | Sale at price 76.88 per share. | 3K | $228.33K |
| Apr 22, 2026 | Hamilton James COfficer | Sale at price 75.00 per share. | 10K | $750.00K |
| Apr 21, 2026 | Apel Daniel JosephChief Financial Officer | Sale at price 70.11 - 71.92 per share. | 13.1K | $934.28K |
| Mar 4, 2026 | Hamilton James COfficer | Sale at price 64.19 per share. | 10K | $641.90K |
| Jan 5, 2026 | O'Brien Patrick CChief Operating Officer | Stock Gift at price 0.00 per share. | 2.5K | — |
| Jan 5, 2026 | O'Brien Patrick CChief Operating Officer | Stock Award(Grant) at price 0.00 per share. | 75K | — |
| Jan 5, 2026 | Hamilton James COfficer | Stock Award(Grant) at price 0.00 per share. | 75K | — |
| Jan 5, 2026 | Apel Daniel JosephChief Financial Officer | Stock Award(Grant) at price 0.00 per share. | 75K | — |
| Jan 4, 2026 | O'Brien Patrick CChief Operating Officer | Sale at price 61.12 - 68.00 per share. | 49.5K | $3.12M |
| Jan 4, 2026 | Hamilton James COfficer | Sale at price 61.24 - 68.00 per share. | 40.2K | $2.53M |
| Jan 1, 2026 | Anzalone Christopher RichardChief Executive Officer | Sale at price 65.88 - 66.39 per share. | 13.2K | $871.70K |
| Dec 30, 2025 | O'Brien Patrick CChief Operating Officer | Stock Gift at price 0.00 per share. | 2.8K | — |
| Dec 28, 2025 | Anzalone Christopher RichardChief Executive Officer | Sale at price 68.69 - 69.33 per share. | 51.7K | $3.58M |
| Dec 28, 2025 | Anzalone Christopher RichardChief Executive Officer | Conversion of Exercise of derivative security at price 6.15 per share. | 51.7K | $318.12K |
| Dec 25, 2025 | Ferrari MauroDirector | Sale at price 70.00 per share. | 7.5K | $527.10K |
| Dec 21, 2025 | Anzalone Christopher RichardChief Executive Officer | Sale at price 66.67 - 68.85 per share. | 26K | $1.77M |
| Dec 18, 2025 | Olukotun Adeoye YDirector | Sale at price 66.70 - 68.48 per share. | 10K | $676.62K |
| Year | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec | Year |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026 | 4.4 | -8.7 | -0.9 | 17.2 | 6.0 | 4.6 | 3.9 | -2.7 | -20.6 | -10.1 | −11.4% | ||
| 2025 | 5.7 | -4.9 | -32.6 | 9.0 | 15.7 | -1.7 | 0.0 | 39.4 | 56.6 | 22.9 | 24.3 | 26.0 | +253.1% |
| 2024 | 4.9 | 0.0 | -10.9 | -20.9 | 1.5 | 13.2 | 9.9 | -16.6 | -18.7 | -0.7 | 35.4 | -27.8 | −38.6% |
| 2023 | -13.7 | -7.7 | -21.4 | 39.4 | -2.8 | 3.6 | -3.2 | -19.9 | -2.8 | -8.5 | -13.8 | 44.3 | −24.6% |
| 2022 | -20.4 | -16.6 | 4.5 | -10.6 | -18.9 | 5.5 | 20.8 | -6.6 | -16.8 | 5.3 | -7.5 | 26.0 | −38.8% |
| 2021 | 0.6 | 3.2 | -16.8 | 9.7 | -0.2 | 14.1 | -16.3 | -3.1 | -7.0 | 2.2 | 9.8 | -5.4 | −13.6% |
| 2020 | -33.9 | -15.6 | -18.6 | 19.7 | -6.4 | 34.0 | -0.3 | -1.9 | 1.9 | 33.1 | 9.1 | 22.7 | +21.0% |
| 2019 | 13.7 | 38.2 | -6.0 | -2.0 | 31.9 | 11.8 | 9.7 | 17.6 | -17.5 | 42.1 | 82.3 | -13.1 | +410.7% |
| 2018 | 67.9 | 4.9 | 11.3 | -11.0 | 67.0 | 26.9 | 7.1 | 1.3 | 29.9 | -33.6 | 14.2 | -14.5 | +237.5% |
| 2017 | 25.2 | 16.5 | -18.1 | -16.2 | -7.1 | 12.5 | 8.6 | 59.1 | 54.6 | -15.9 | -1.9 | 3.1 | +137.4% |
| 2016 | -43.4 | 12.1 | 23.6 | 20.1 | 5.9 | -13.2 | 12.0 | 16.3 | 6.1 | -21.1 | -75.2 | 7.6 | −74.8% |
| 2015 | -14.5 | 19.3 | -10.2 | 2.0 | -8.7 | 13.5 | -13.6 | -4.0 | -2.9 | -10.6 | 22.7 | -2.7 | −16.7% |
| 2014 | 41.4 | 26.7 | -15.5 | -33.5 | 15.2 | 13.8 | -11.6 | 15.2 | 1.4 | -55.9 | -10.7 | 26.8 | −32.0% |
| 2013 | -9.3 | 11.3 | 1.0 | -5.5 | 6.8 | -9.1 | 88.5 | 10.1 | 37.1 | 23.0 | 17.6 | 31.8 | +407.0% |
| 2012 | 12.9 | 14.0 | 18.4 | -9.2 | -30.9 | -4.0 | -3.6 | -27.6 | -2.2 | -3.8 | -12.3 | -3.2 | −48.9% |
| 2011 | -2.8 | -21.8 | 10.3 | -19.7 | -10.3 | -5.6 | 3.9 | 3.8 | -29.1 | 29.2 | 22.4 | -32.1 | −53.2% |
| 2010 | 7.5 | -7.0 | 115.1 | 34.2 | -11.8 | -18.5 | 6.4 | -22.2 | 15.4 | -5.9 | -3.8 | -5.8 | +68.9% |
| 2009 | -5.4 | -55.2 | 43.6 | 14.3 | -18.8 | -15.4 | 10.2 | -4.3 | 43.3 | -21.8 | 15.4 | -11.7 | −42.4% |
| 2008 | -16.9 | -22.3 | 16.0 | -5.3 | -7.8 | 0.8 | -15.3 | -17.1 | -40.6 | 15.4 | 6.7 | -28.1 | −75.7% |
| 2007 | -6.0 | -7.9 | 18.0 | 44.0 | 18.0 | -33.8 | -10.3 | 8.2 | 3.5 | -18.2 | -1.2 | -7.4 | −13.7% |
Arrowhead Pharmaceuticals, Inc. develops medicines for the treatment of intractable diseases in the United States. Its pipeline includes Plozasiran to reduce production of apolipoprotein C-III in Phase 3 studies; Zodasiran to reduce production of angiopoietin-like protein 3 in Phase 3 clinical trials; ARO-DIMER-PA, a dual functional RNAi molecule in a Phase 1/2a clinical trials; and ARO-PNPLA3, an investigational RNAi therapeutic in Phase 1 clinical trials. The company also develops ARO-INHBE, to reduce the hepatic expression of the INHBE gene and its secreted gene product, Activin E in Phase 1/2a clinical trials; ARO-ALK7 to silence adipocyte expression of the ACVR1C gene in Phase 1/2a clinical trials; ARO-RAGE to reduce production of the receptor for advanced glycation end products in Phase 1/2a clinical trials; and ARO-MAPT, an investigational RNAi-based therapy. In addition, it is developing ARO-C3 to reduce production of C3 in Phase 1/2a clinical trials; and ARO-CFB to reduce hepatic expression of CFB in a Phase 1/2a clinical trials. The company has collaboration and license Agreements with Glaxosmithkline Intellectual Property (No. 3) Limited; Takeda Pharmaceutical Company Limited; Amgen Inc.; and Sarepta Therapeutics, Inc. Arrowhead Pharmaceuticals, Inc. was founded in 2003 and is headquartered in Pasadena, California.
Buy / hold / sell counts