UPB
Upstream Bio, Inc.Closed3.55−0.62 −14.87%USD
NasdaqGS · as of Oct 13, 16:00 ET · 15m delayAfter hours 3.59 +1.13%
Open
4.14
Prev close
4.17
Day range
3.524.16
52-week range
3.5233.68
Volume
1.04M1.55×
Mkt cap
194.44M
P/E ttm
—
Fwd P/E
-1.27
EPS ttm
-2.88
Div yield
0.00%
Earnings
Aug 11, 2026
From 52w high
−89.46%
UPB shareholders
UPB Ownership
13F / N-PORT filings via Yahoo
Institutions
92.4%
108.5% of the float
Insiders
14.8%
officers and directors
Institutional holders
199
filing positions
Top 10 institutions
57.8%
7 adding · 0 trimming
Top Institutions
| Holder | % held | Shares | Value | Change | As of |
|---|---|---|---|---|---|
| FMR, LLC | 14.90% | 8.16M | $28.98M | +0.8% | Jun 30, 2026 |
| Orbimed Advisors LLC. | 10.40% | 5.69M | $20.21M | 0.0% | Jun 30, 2026 |
| NORGES BANK | 6.88% | 3.77M | $13.38M | +30.7% | Jun 30, 2026 |
| Blackrock Inc. | 6.85% | 3.75M | $13.32M | +11.4% | Jun 30, 2026 |
| Decheng Capital LLC | 4.98% | 2.72M | $9.67M | 0.0% | Jun 30, 2026 |
| Enavate Sciences Gp, LLC | 4.49% | 2.46M | $8.73M | 0.0% | Jun 30, 2026 |
| Vanguard Capital Management LLC | 3.43% | 1.88M | $6.66M | +0.2% | Jun 30, 2026 |
| Millennium Management Llc | 2.09% | 1.14M | $4.06M | +22.0% | Jun 30, 2026 |
| Shaw D.E. & Co., Inc. | 1.89% | 1.04M | $3.68M | +26.3% | Jun 30, 2026 |
| JPMORGAN CHASE & CO | 1.85% | 1.01M | $3.59M | +118.6% | Jun 30, 2026 |
Top Funds
| Holder | % held | Shares | Value | Change | As of |
|---|---|---|---|---|---|
| VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund | 2.63% | 1.44M | $5.12M | 0.0% | Jun 30, 2026 |
| Fidelity Securities Fund-Fidelity Small Cap Growth Fund | 2.50% | 1.37M | $4.87M | 0.0% | Jul 31, 2026 |
| Fidelity Capital Trust-Fidelity Stock Selector Small Cap Fund | 2.41% | 1.32M | $4.69M | 0.0% | Jul 31, 2026 |
| Fidelity Securities Fund-Fidelity Series Small Cap Opportunities Fund | 1.76% | 965.80K | $3.43M | 0.0% | Jul 31, 2026 |
| iShares Trust-iShares Russell 2000 ETF | 1.66% | 907.20K | $3.22M | +0.7% | Aug 31, 2026 |
| Fidelity Select Portfolios-Select Health Care Portfolio | 1.46% | 800.00K | $2.84M | 0.0% | Aug 31, 2026 |
| Fidelity Securities Fund-Fidelity Small Cap Growth K6 Fund | 1.27% | 693.62K | $2.46M | 0.0% | Jul 31, 2026 |
| Fidelity Advisor Series VII-Fidelity Advisor Biotechnology Fund | 1.26% | 691.00K | $2.45M | 0.0% | Aug 31, 2026 |
| Fidelity Advisor Series VII-Fidelity Advisor Health Care Fund | 0.73% | 400.00K | $1.42M | 0.0% | Aug 31, 2026 |
| VANGUARD INDEX FUNDS-Vanguard Extended Market Index Fund | 0.71% | 386.88K | $1.37M | +0.9% | Jun 30, 2026 |
Institutions report quarterly, up to 45 days after the quarter ends, so these positions can be months old. Change compares the share count with the holder's previous filing. Insider transactions are on the overview page (INSD).