| Aug 3, 2026 | Azoulay Salomon M.D.Officer | Sale at price 65.77 per share. | 370 | $24.34K |
| Aug 2, 2026 | Hoerter Steven LChief Executive Officer | Stock Award(Grant) at price 0.00 per share. | 71K | — |
| Aug 2, 2026 | Smither John WChief Financial Officer | Stock Award(Grant) at price 0.00 per share. | 28K | — |
| May 7, 2026 | Azoulay Salomon M.D.Officer | Sale at price 38.30 - 38.38 per share. | 70K | $2.69M |
| May 7, 2026 | Azoulay Salomon M.D.Officer | Conversion of Exercise of derivative security at price 10.46 - 16.00 per share. | 70K | $815.35K |
| May 5, 2026 | Hawryluk P KentChief Executive Officer | Sale at price 29.54 per share. | 607 | $17.93K |
| May 5, 2026 | Azoulay Salomon M.D.Officer | Sale at price 29.54 per share. | 231 | $6.82K |
| Apr 30, 2026 | Hoerter Steven LDirector | Stock Award(Grant) at price 0.00 per share. | 11.9K | — |
| Mar 12, 2026 | Hawryluk P KentChief Executive Officer | Purchase at price 28.41 per share. | 18.5K | $525.66K |
| Feb 25, 2026 | Hawryluk P KentChief Executive Officer | Conversion of Exercise of derivative security at price 16.00 per share. | 28.8K | $460.29K |
| Feb 1, 2026 | Hawryluk P KentChief Executive Officer | Stock Award(Grant) at price 0.00 per share. | 35.3K | — |
| Feb 1, 2026 | Bartram Richard BChief Financial Officer | Stock Award(Grant) at price 0.00 per share. | 15K | — |
| Feb 1, 2026 | Azoulay Salomon M.D.Officer | Stock Award(Grant) at price 0.00 per share. | 15K | — |
| Oct 23, 2025 | Hawryluk P KentChief Executive Officer | Conversion of Exercise of derivative security at price 3.25 per share. | 182.9K | $594.29K |
| Oct 19, 2025 | Hawryluk P KentChief Executive Officer | Purchase at price 13.64 per share. | 20K | $272.79K |
| Oct 16, 2025 | Hoerter Steven LDirector | Purchase at price 13.25 per share. | 20K | $264.98K |
| Sep 25, 2025 | Heron Patrick JDirector and Beneficial Owner of more than 10% of a Class of Security | Purchase at price 18.00 per share. | 666.7K | $12.00M |
| Apr 7, 2025 | Pescovitz Ora HDirector | Purchase at price 5.89 per share. | 7.7K | $45.31K |
| Feb 17, 2025 | Gordon Carl LDirector and Beneficial Owner of more than 10% of a Class of Security | Purchase at price 9.85 - 10.84 per share. | 190.7K | $2.02M |
| Feb 17, 2025 | Orbimed Advisors, L.L.C.Director and Beneficial Owner of more than 10% of a Class of Security | Purchase at price 9.85 - 10.84 per share. | 190.7K | $2.02M |
